Experimental Economics and Game Theory Seminar for September 21

Events, Seminars | September 7, 2018

Join us for the ICES Seminar in Experimental Economics and Game Theory of the Fall 2018 semester, featuring Jonathan Beauchamp.

Prof. Beauchamp, of University of Toronto, will discuss his paper Genome-wide Study Identifies 611 Loci Associated with Risk Tolerance 2 and Risky Behaviors (Abstract). The talk will take place on Friday, September 21st, from 4:00 to 5:00pm in room 5183 of Vernon Smith Hall (formerly Metropolitan Building), Arlington campus.
Visit the Seminar schedule to access the paper and to learn more about upcoming speakers.

Abstract

Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences across general risk tolerance and risky behaviors: 72 of the 124 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is moderately to strongly genetically correlated (|rˆg| ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We find no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

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